Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)ethanone Derivatives

Vinaya, K. and Kavitha, C. V. and Prasanna, D. S. and Chandrappa, S. and Ranganatha, S. R. and Raghavan, S. C. and Rangappa, K. S. (2012) Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)ethanone Derivatives. Chemical Biology & Drug Design, 79 (3). pp. 360-367. ISSN 1747-0285

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Abstract

A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl)ethanone derivatives 9(a–e) and 10(a–g) were synthesized and characterized by 1H NMR, IR, mass spectral, and elemental analysis. These novel compounds were evaluated for their antileukemic activity against two human leukemic cell lines (K562 and CEM) by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. Some of the tested compounds showed good antiproliferative activity with IC50 values ranging from 1.6 to 8.0 μm. Compound 9c, 9e, and 10f with an electron-withdrawing halogen substituent at the para position on the phenyl ring showed excellent in vitro potency against tested human leukemia cells (K562 and CEM).

Item Type:	Article
Uncontrolled Keywords:	1, 3-dimethoxy benzene, Anticancer agents, Cell death, Leukemia, MTT assay, Piperidine
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	23 Jul 2019 05:51
Last Modified:	23 Jul 2019 05:51
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5454

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