Ordering of the water molecule in the crystal structure of 2-3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-PyridinylMethylthio-1H-Benzimidazole Hydrate (Lansoprazole Sulphide Hydrate)

Kubicki, Maciej and Dutkiewicz, Grzegorz and Jasinski, Jerry P. and Butcher, Ray J. and Siddegowda, M. S. and Yathirajan, H. S. and Narayana, B. (2012) Ordering of the water molecule in the crystal structure of 2-3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-PyridinylMethylthio-1H-Benzimidazole Hydrate (Lansoprazole Sulphide Hydrate). Journal of Chemical Crystallography, 42 (3). pp. 245-250. ISSN 1572-8854

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Abstract

Lansoprazole sulphide (2-3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylthio-1H-benzimidazole) hydrate crystallizes in the triclinic space group P-1 with two molecules in the asymmetric part of the unit cell. The molecules are almost identical, the normal probability plots show that the differences between them are of statistical nature. The crystal structure is determined mainly by the O--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}N and N--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}O hydrogen bonds; and both symmetry independent molecules create the hydrogen-bonded structures on their own. The common motif is the C22(6) chain of molecules along x (A) or y (B), but the interactions between the chains are different: chains of molecules A are joined by O--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}N(pyridine) hydrogen bonds while those of molecules B-- by relatively strong O--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}S hydrogen bonds. Additionally, in both cases there are also C--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}S, C--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}$\pi$ and $\pi$--$\pi$ interactions between the neighbouring molecules. The different intermolecular interactions might be connected with the observed disorder of water molecules in the B-chains. At room temperature the s.o.f.'s of two alternative positions refined at 0.760(17) and 0.240(17). The less-occupied water molecule does not take part in the O--H{\textperiodcentered}{\textperiodcentered}{\textperiodcentered}S hydrogen bonding. When temperature decreases the importance of this interaction grows, the occupancy of less occupied position becomes smaller and finally, around 150 K the structure becomes fully ordered.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	23 Jul 2019 05:20
Last Modified:	23 Jul 2019 05:20
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5447

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