In vivo peritoneal antiangiogenesis and in vitro antiproliferative properties of some bischalcone derivatives

Darshan Raj, C. G. and Sarojini, B. K. and Ramakrishna, M. K. and Ramesh, S. R. and Manjunatha, H. (2012) In vivo peritoneal antiangiogenesis and in vitro antiproliferative properties of some bischalcone derivatives. Medicinal Chemistry Research, 21 (4). pp. 453-458. ISSN 1554-8120

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Official URL: https://doi.org/10.1007/s00044-011-9551-2

Abstract

In this study, three, bisarylidene cyclopentanones (curcumin analogs) 3a--c are synthesized by Claisen Schmidt condensation reaction. Antiangiogenic effects of the compounds were studied in Ehrlich ascites tumor (EAT) cells transplanted mouse in vivo. Antiangiogenic effect of 3a--c showed reduction in ascites volume, cell number, and induced apoptotic bodies in EAT cells in tested animals. The antiproliferative effects of the 3a--c were determined at different concentrations by MTT assay on HepG2 and HeLa cells. The compounds showed significant antiproliferative activity at 40 μM concentration. Compound 3a (fluoro derivative) showed highest antiproliferative effect with the IC50 value 39 and 48 μm for HeLa and HepG2, respectively. Growth inhibition of the HeLa cells and antiangiogenesis was mediated by promoting apoptosis which was confirmed by DNA fragmentation study.

Item Type: Article
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: MUL SWAPNA user
Date Deposited: 22 Jul 2019 10:41
Last Modified: 22 Jul 2019 10:41
URI: http://eprints.uni-mysore.ac.in/id/eprint/5443

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