Spectrophotometric determination of quetiapine fumarate in pharmaceuticals and human urine by two charge-transfer complexation reactions

Vinay, K. B. and Revenasiddappa, H. D. (2017) Spectrophotometric determination of quetiapine fumarate in pharmaceuticals and human urine by two charge-transfer complexation reactions. Chemical Industry and Chemical Engineering Quarterly, 18 (2). pp. 263-272. ISSN 2217-7434

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Abstract

Two simple, rapid and accurate spectrophotometric procedures are proposed for the determination of quetiapine fumarate (QTF) in pharmaceuticals and in spiked human urine. The methods are based on charge transfer complexation reactions of free base form of the drug (quetiapine, QTP), as n-electron donor (D), with either p-chloranilic acid (p-CAA) (method A) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) (method B) as pi-acceptors (A). The coloured charge transfer complexes produced exhibit absorption maxima at 520 and 540 nm, in methods A and B, respectively. The experimental conditions such as reagent concentration, reaction solvent and time have been carefully optimized to achieve the maximum sensitivity. Beer's law is obeyed over the concentration ranges of 8.0-160 and 4.0-80.0 mu g mL(-1), for methods A and B, respectively. The calculated molar absorptivity values are 1.77x10(3) and 4.59x10(3) I mol(1) cm(-1), for methods A and B, respectively. The Sandell sensitivity values, limits of detection (LOD) and quantification (LOQ) have also been reported. The stoichiometly of the reaction in both cases was accomplished adopting the limiting logarithmic method and was found to be 1:2 (D:A). The accuracy and precision of the methods were evaluated on intra-day and inter-day basis. The proposed methods were successfully applied for the determination of QTF in pharmaceutical formulations and spiked human urine.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	22 Jul 2019 09:46
Last Modified:	22 Jul 2019 09:46
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5432

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