Spectrophotometric determination of quetiapine fumarate through ion-pair complexation reaction with tropaeolin ooo

Vinay, K. B. and Revanasiddappa, H. D. (2012) Spectrophotometric determination of quetiapine fumarate through ion-pair complexation reaction with tropaeolin ooo. Indian Journal of Chemical Technology, 19 (3). pp. 205-212. ISSN 0971-457X

Text (Full Text) Spectrophotometric determination of quetiapine.pdf - Published Version Restricted to Registered users only Download (119kB) | Request a copy

Abstract

A sensitive, rapid and reproducible spectrophotometric method for the determination of quetiapine fumarate (QTF), an antipsychotic drug, in bulk drug, tablets and human urine has been developed and validated. The method includes the formation of a 1:2 chloroform extractable ion-pair complex between the drug and the dye tropaeolin ooo (TP) in acidic medium (pH 1.83±0.03). The resulting orange-red coloured ion-pair complex exhibits an absorption maximum at 480 nm. The optimum conditions for the ion-pair formation have also been established. The method permits the determination of QTF over a concentration range 2.0 – 20.0 µg mL-1. The apparent molar absorptivity and Sandell sensitivity values are found to be 2.30 × 104 Lmol-1cm-1 and 0.0264 µg cm-2 respectively. The limits of quantitation and detection values are also reported. The accuracy and precision results of the method evaluated on intra-day and inter-day basis are found to be satisfactory. The proposed method has been successfully applied to the determination of QTF in bulk drug, tablets and spiked human urine with satisfactory results. The excipients from the tablets and other basic substances present in urine do not interfere in the assay.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	22 Jul 2019 06:17
Last Modified:	22 Jul 2019 06:17
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5423

Actions (login required)

View Item