Nutrition and nutraceuticals in neuroinflammatory and brain metabolic stress: Implications for neurodegenerative disorders

Pandareesh, M. D. and Hemanth Kumar, K. and Sakina Razack and Amruta, N. and Choudhari, Ramesh and Ajit Vikram and Prakash, D. (2018) Nutrition and nutraceuticals in neuroinflammatory and brain metabolic stress: Implications for neurodegenerative disorders. CNS & Neurological Disorders - Drug Targets, 17 (9). pp. 680-688. ISSN 1996-3181

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Official URL: https://doi.org/10.1016/10.2174/187152731766618062...

Abstract

Background and Objective: A steep rise in the incidences of neurodegenerative disorders could be the combined effect of several non-genetic factors such as increased life expectancy, environmental pollutants, lifestyle, and dietary habits, as population-level genetic change require multiple generations. Emerging evidence suggests that chronic over-nutrition induces brain metabolic stress and neuroinflammation, and are individually known to promote neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Although the association of metabolic disorders such as diabetes, hypertension, dyslipidemia, and atherosclerosis with the dietary habits is well known, neuronal implications of diet and nutritional factors is still in its infancy. Transcriptomics and proteomics-based studies support the view that nutraceuticals target multiple neuroprotective pathways in a slow but effective manner without causing severe adverse effects, and may represent the future of tackling neurodegenerative disorders.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: manjula User
Date Deposited: 20 Jul 2019 07:59
Last Modified: 20 Jul 2019 07:59
URI: http://eprints.uni-mysore.ac.in/id/eprint/5405

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