Analytical utility of potassium permanganate for the assay of albendazole in bulk drug and pharmaceuticals

Nagaraju Swamy and Prashanth, K. N. and Basavaiah, K. (2015) Analytical utility of potassium permanganate for the assay of albendazole in bulk drug and pharmaceuticals. Journal of Reports in Pharmaceutical Sciences, 4 (1). pp. 12-23.

Full text not available from this repository. (Request a copy)

Abstract

Two rapid, simple, sensitive and cost-effective titrimetric and spectr-ophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in pharmaceuticals. In titrimetry (method A), ALB is oxidized by a known excess of potassium permanganate (KMnO4) in H2SO4 medium followed by the determination of unreacted permanganate by titration with ferrous ammonium sulphate (FAS). In spectrophotometry (method B), ALB is treated with a measured excess of permanganate in acid medium and the unreacted oxidant is measured at 545 nm. The molar ratio (stoichiometry) in titrimetry and the optimum assay conditions are studied. Titrimetry is applicable over 2-9 mg range and the calculations are based on a 1:1 (ALB: KMnO4) molar-ratio. In spectrophotometry, Beers law is obeyed over 8.0-64.0 µg mL-1 concentration range of ALB. The molar absorptivity and Sandell sensitivity values are calculated to be 3.348 103 L mol-1 cm-1 and 0.08 µg cm-2, respectively. The limits of detection (LOD) and quantification (LOQ) are also reported for the spectrophotometric method. The applicability of the developed methods is demonstrated by the assay of ALB in pure drug as well as in commercial formulations.

Item Type: Article
Uncontrolled Keywords: Albendazole and Assay and Titrimetry and Spectrophotometry and Permanganate and Formulations
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 20 Jul 2019 05:26
Last Modified: 20 Jul 2019 05:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/5390

Actions (login required)

View Item View Item