Antimetastatic activity of tinospora cordifolia involves inhibition of cell migration and invasion regulated by twist and snail genes

Shilpa, P. and Yashaswini, B. and Bharathi, P. (2015) Antimetastatic activity of tinospora cordifolia involves inhibition of cell migration and invasion regulated by twist and snail genes. IOSR Journal of Pharmacy and Biological Sciences, 10 (2). pp. 44-49. ISSN 2319-7676

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Abstract

VEGF-mediated signalling facilitates survival and metastasis of tumour cells. The metastatic cascade follows tumour cell dissemination, passage through the blood and/or lymphatic system, and colonisation at a distant site. Increased cell motility of cancer cells at the leading tumour edge has been attributed to the epithelial mesenchymal transition (EMT) which facilitates their release and invasiveness. Breast cancers which exhibit properties of EMT are highly aggressive and resistant to therapy. In the present study, two molecules from hexane and methanolfractions (T1 and T2)from the plant Tinospora cordifoliawere chosen to verify the anti-metastatic activity. Our data show that inMCF-7 cells,T1 treatment significantly suppressed the proliferation, migration and invasion of MCF-7cells when compared to that of T2. EMT-related genes, Twist and Snail, were downregulated by T1 with increased transcription of E-cadherin. Overall, our results demonstrate that T1 down-regulates Twist and Snail genes involvedin proliferation, migration and invasion.

Item Type: Article
Uncontrolled Keywords: Epithelial-Mesenchymal Transition and Tinospora Cordifolia and Metastasis and Vascular Endothelial Growth Factor (VEGF)
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Shrirekha N
Date Deposited: 19 Jul 2019 05:24
Last Modified: 19 Jul 2019 05:24
URI: http://eprints.uni-mysore.ac.in/id/eprint/5358

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