Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines

Samshuddin, S. and Narayana, B. and Sarojini, B. K. and Khan, Mahmud Tareq Hassan and Yathirajan, H. S. and Darshan Raj, C. G. and Raghavendra, R. (2012) Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines. Medicinal Chemistry Research, 21 (8). pp. 2012-2022. ISSN 1554-8120

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Official URL: https://doi.org/10.1007/s00044-011-9735-9

Abstract

A series of 1,3,5-triaryl-2-pyrazolines 2a--g were synthesized by the reaction of 4,4´x-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl-tRNA synthetase (metRS). Some of the tested compounds exhibited significant antimicrobial, analgesic, DPPH scavenging activities and molecular binding.

Item Type: Article
Uncontrolled Keywords: Analgesic, Antimicrobial, DPPH scavenging assay, 1,3,5-Triaryl-2-pyrazoline, Molecular docking metRS, Molecular recognition
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 18 Jul 2019 05:32
Last Modified: 18 Jul 2019 05:32
URI: http://eprints.uni-mysore.ac.in/id/eprint/5330

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