Synthesis, antibacterial, antioxidant and anti-inflammatory activities of new benzimidazole derivatives

Shivaprasad, C. M. and Jagadish, S. and Swaroop, T. R. and Roopashree, R. and Mohan, C. D. and Rakesh, K. S. and Raghava, B. and Subbegowda, K. (2015) Synthesis, antibacterial, antioxidant and anti-inflammatory activities of new benzimidazole derivatives. Asian Journal Of Biochemical and Pharmaceutical Research, 5 (4). pp. 71-81. ISSN 2249 – 622X

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Abstract

New benzimidazole derivatives were synthesized and tested for their antibacterial, anti-oxidant and anti-inflammatory activities. Most of the new compounds exhibit moderate antibacterial activity against Gram Negative bacterial strains (E. coli, K. pneumonia, S. typhi and S. flexneri). In addition, the molecules were investigated for anti-oxidant activities by super oxide radical, DPPH (2,2-Diphenyl-1-picrylhydrazyl), and hydroxyl radical scavenging assays, where most of the compounds displayed significant antioxidant activities. Furthermore, these benzimidazoles were evaluated for anti-inflammatory activity by indirect haemolytic and lipoxygenase inhibition assays where compounds revealed good activity.

Item Type: Article
Uncontrolled Keywords: Benzimidazole and Antibacterial and Antioxidant and Anti-Inflammatory and Synthesis and Activity.
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 18 Jul 2019 05:21
Last Modified: 18 Jul 2019 05:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/5327

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