Design and synthesis of tryptophan containing peptides as potential analgesic and anti-inflammatory agents

Suhas, R. and Channe Gowda, D. (2012) Design and synthesis of tryptophan containing peptides as potential analgesic and anti-inflammatory agents. Journal of Peptide Science, 18 (8). pp. 535-540. ISSN 1099-1387

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Abstract

A new series of smaller peptides with tryptophan at C-terminal and varying N-protected amino acids/peptides were designed, synthesized and characterized by analytical and spectroscopic techniques. Analgesic and anti-inflammatory properties of these peptides were carried out in vivo using tail-flick method and carrageenan-induced paw edema method, respectively, at different doses and different time intervals. Most of the peptides synthesized displayed enhanced activity, and particularly tetra and hexapeptides 29–31 were found to be even more potent than the reference standards used. Moreover, some peptides have exhibited promising activity even after 24 h of administration, whereas the reference standards were active only up to 3 h. Further, the compounds did not present any ulcerogenic liability. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.

Item Type:	Article
Uncontrolled Keywords:	indole, synthesis, peptides, analgesics, anti-inflammatory agents
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	18 Jul 2019 05:13
Last Modified:	18 Jul 2019 05:13
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5325

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