Evaluation of anti-diabetic effect of Trigonella foenum graecum Linn. Leaf extract in streptozotocin induced diabetic rats

Ramya, P. and Lakshmidevi, N. and Jayashree, K. and Suresh, R. N. (2012) Evaluation of anti-diabetic effect of Trigonella foenum graecum Linn. Leaf extract in streptozotocin induced diabetic rats. International Journal of Diabetes in Developing Countries, 32 (3). pp. 138-144. ISSN 1998-3832

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Official URL: https://doi.org/10.1007/s13410-012-0081-3

Abstract

Trigonella foenum graecum leaves are widely used as a vegetable throughout India and have a long history of medicinal use in Ayurveda and Chinese medicine. Even though the leaves of this plant are used in diabetes mellitus, there have been no in vivo studies to prove its efficacy. The aim of this study was to know the efficacy of ethanol extract of T. foenum graecum leaves on blood glucose levels, antioxidant enzymes, islets cells of pancreas, creatinine and urea levels in normal and streptozotocin induced diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg b.w. in 0.9 % cold saline). Two doses (250 and 500 mg/kg b.w.) of the extracts were administered in the study. The activity was compared with the reference standard glibenclamide (0.5 mg/kg b.w.) for various biochemical and histopathological parameters. The data was analysed by one way ANOVA followed by Turkey's post hoc test. The activity of the extract in reducing blood glucose, creatinine and urea levels, in enhancing antioxidant enzyme activity and restoring and regenerating islet cells of pancreas was comparable to glibenclamide. The result suggests that ethanol leaf extract of T. foenum graecum possesses significant antidiabetic property.

Item Type: Article
Uncontrolled Keywords: Diabetic rats, Trigonella foenum graecum, Antihyperglycemic effect, Antioxidant enzyme activity
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: C Swapna Library Assistant
Date Deposited: 17 Jul 2019 06:12
Last Modified: 17 Jul 2019 06:12
URI: http://eprints.uni-mysore.ac.in/id/eprint/5299

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