In vitro biological activity of aromadendrin-4²-methyl ether isolated from root extract of ventilago madraspatana gaertn with relevance to anticandidal activity

Rajesh, P. S. and Samaga, Pradeepa V. and Rai, Ravishankar V. and Rai, Lokanatha K. M. (2015) In vitro biological activity of aromadendrin-4²-methyl ether isolated from root extract of ventilago madraspatana gaertn with relevance to anticandidal activity. Natural Product Research, 29 (11). pp. 1042-1045. ISSN 1478-6427

Full text not available from this repository. (Request a copy)
Official URL: http://doi.org/10.1080/14786419.2014.968152

Abstract

In this study, antimicrobial and antioxidant activities of the hexane extract of the root of Ventilago madraspatana were evaluated. Based on the significant bioactivity of crude hexane extract, an active compound was purified from the root extract. The active compound was further purified and identified as aromodendrin-40-methyl ether by the 1H NMR spectrum. The isolated compound significantly inhibited Staphylococcus epidermidis with the lowest MIC and MBC at 78 mg/mL (P , 0.05). The compound also exhibited significant anticandidal activity with MIC and MBC values of 312 and 625mg/mL, respectively. The radical scavenging activity of aromodendrin-40-methyl ether was evident by its lower IC50 values of 60mg/mL for DPPH scavenging and 3.2mg/mL for ABTS scavenging. The compound also exhibited ferrous ion chelation and H2O2 scavenging activities. The study is an attempt to increase the industrial utility of V. madrasapatana.

Item Type: Article
Uncontrolled Keywords: <I>Ventilago Madraspatana</I> and Antibacterial and Antioxidant and Anticandidal and DPPH
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: Shrirekha N
Date Deposited: 17 Jul 2019 05:56
Last Modified: 17 Jul 2019 05:56
URI: http://eprints.uni-mysore.ac.in/id/eprint/5292

Actions (login required)

View Item View Item