In Vivo prophylactic effects of oleanolic acid isolated from chloroform extract of Flaveria trinervia against ethanol induced liver toxicity in rats

Joy Hoskeri, H. and Krishna, V. and Vinay Kumar, B. and Shridar, A. H. and Ramesh Babu, K. and Sudarshana, M. S. (2012) In Vivo prophylactic effects of oleanolic acid isolated from chloroform extract of Flaveria trinervia against ethanol induced liver toxicity in rats. Archives of Pharmacal Research, 35 (10). pp. 1803-1810. ISSN 1976-3786

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Official URL: https://doi.org/10.1007/s12272-012-1013-y

Abstract

The prophylactic effects of oleanolic acid (OA) isolated from chloroform extract (CE) of Flaveria trinervia against ethanol induced liver toxicity was investigated using rats. CE and OA at three different doses were tested by administering orally to the ethanol treated animals during the last week of the 7 weeks study. Silymarin was used as the standard reference. The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase and bilirubin in ethanol treated animals were restored towards normalcy by treatment of CE and OA. In vivo antioxidant and in vitro free radical scavenging activities were also positive for all the three concentrations of CE and OA. However, OA at 150 mg/kg showed significant activity when compared to the other two doses. Biochemical observations in support with histopathological examinations revealed that CE and OA possess hepatoprotective action against ethanol induced hepatotoxicity in rats.

Item Type: Article
Uncontrolled Keywords: Alcoholic hepatotoxicity, Hepatoprotective, Antioxidant, Oleanolic acid (OA), Chloroform extract (CE), Flaveria trinervia
Subjects: B Life Science > Botany
Divisions: Department of > Botany
Depositing User: C Swapna Library Assistant
Date Deposited: 16 Jul 2019 06:03
Last Modified: 16 Jul 2019 06:03
URI: http://eprints.uni-mysore.ac.in/id/eprint/5248

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