Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives

Benaka Prasad, S. B. and Vinaya, K. and Ananda Kumar, C. S. and Swarup, S. and Rangappa, K. S. (2010) Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives. Medicinal Chemistry Research, 19 (3). pp. 220-235. ISSN 1554-8120

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Official URL: https://doi.org/10.1007/s00044-009-9186-8

Abstract

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a--n) were synthesized and characterized by 1H NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: LA manjunath user
Date Deposited: 15 Jul 2019 10:00
Last Modified: 17 Jun 2022 10:46
URI: http://eprints.uni-mysore.ac.in/id/eprint/5201

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