Shivakumar, L. and Shivaprasad, K. and Revanasiddappa, H. D. (2012) Synthesis, spectroscopic characterization, antimicrobial,DNA binding and oxidative-induced DNA cleavage activities: new oxovanadium(IV) complexes of 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 97. 659 - 666. ISSN 1873-3557
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A mononuclear complex (phen)VO(bid)SO4·3H2O (1), (phen=1,10-phenanthroline) and a binuclear (VObid)2·H2O (2), with Hbid (E)-2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione were prepared and characterized by elemental analysis, IR, mass, UV–Vis spectral studies, ESR, molar conductance and thermogravimetric analysis. The DNA-binding properties of the complexes 1 and 2 were investigated by UV–spectroscopy, fluorescence spectroscopy and viscosity measurements. The superoxide dismutase-like activity of the complexes has been determined. The spectral results suggest that the complexes 1 and 2 can bind to DNA by intercalation. The cleavage properties of these complexes with super coiled pUC19 have been studied using the gel electrophoresis method, where both complexes 1 and 2 displayed chemical nuclease activity in the absence and presence of H2O2 via an oxidative mechanism. All the complexes inhibit the growth of both Gram positive and Gram negative bacteria to competent level. Minimum inhibitory concentration (MIC) was determined by microtiter method.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Oxovanadium(IV) complexes, SOD activity, DNA binding, Oxidative DNA cleavage, Antimicrobial activity |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 15 Jul 2019 09:58 |
| Last Modified: | 15 Jul 2019 09:58 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/5200 |
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