Facile thermal rearrangement of Lorazepam and Oxazepam

Siddegowda, M. S. and Yathirajan, H. S. and Ramakrishna, R. A. (2012) Facile thermal rearrangement of Lorazepam and Oxazepam. Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry, 51 (11). pp. 1628-1632.

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Lorazepam 1, a very well known anti-convulsant undergo facile thermal rearrangement at about 110°C to 6-chloro-4-(o-chlorophenyl)-2-Quinazolinecarboxaldehyde 10 in almost quantitative yield. Oxazepam 2 which is structurally similar, require higher temperature for the similar rearrangement to give 6-chloro-4-phenyl-2-quinazolinecarboxaldehyde 11. However, structurally similar temazepam 3 did not undergo this rearrangement.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 15 Jul 2019 09:43
Last Modified: 15 Jul 2019 09:43
URI: http://eprints.uni-mysore.ac.in/id/eprint/5193

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