Synthesis and antimicrobial activity of quinazolinone conjugated peptides

Suresha, G. P. and Prakasha, K. C. and Kapfo, W. and Chenne Gowda, D. (2010) Synthesis and antimicrobial activity of quinazolinone conjugated peptides. E-Journal of Chemistry, 7 (2). pp. 449-456. ISSN 2090-9810

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Antimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4- dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relationship was evaluated with respect to hydrophobicity, polarity, chain length of peptides and alkyl chain length of quinazolinone. Correlations of analogs with respect to their antimicrobial activity in comparison with conventional drugs and probable mechanism for the activity were discussed.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: LA manjunath user
Date Deposited: 15 Jul 2019 09:35
Last Modified: 23 Dec 2020 10:45

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