Bad phosphorylation as a target of inhibition in oncology

Bui, Ngoc-Linh-Chi and Pandey, Vijay and Zhu, Tao and Ma, Lan and Basappa and Lobie, Peter E. (2018) Bad phosphorylation as a target of inhibition in oncology. Cancer Letters, 415. 177 - 186. ISSN 1872-7980

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Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system development. Interestingly, BAD can be either pro-apoptotic or pro-survival depending on the phosphorylation state of three specific serine residues (human S75, S99 and S118). Expression of BAD and BAD phosphorylation patterns have been shown to influence tumor initiation and progression and play a predictive role in disease prognosis, drug response and chemosensitivity in various cancers. This review aims to summarize the current evidence on the functional role of BAD phosphorylation in human cancer and evaluate the potential utility of modulating BAD phosphorylation in cancer.

Item Type: Article
Uncontrolled Keywords: BAD phosphorylation, Apoptosis, kinase inhibitor, Bcl-2 family
Subjects: C Chemical Science > Organic Chemistry
Divisions: Department of > Organic Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 11 Jul 2019 11:15
Last Modified: 11 Jul 2019 11:15

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