The anti-snake venom properties of Tamarindus indica (Leguminosae) seed extract

Usha Nandini, S. and Nagaraju, S. and Harish Kumar, K. and Vedavathi, M. and Machiah, D. K. and Kemparaju, K. and Vishwanath, B. S. and Gowda, T. Veerabasappa and Girish, K. S. (2006) The anti-snake venom properties of Tamarindus indica (Leguminosae) seed extract. PHYTOTHERAPY RESEARCH, 20 (10). pp. 851-858.

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Official URL: http://dx.doi.org/10.1002/ptr.1951

Abstract

In Indian traditional medicine, various plants have been used widely as a remedy for treating snakebites. The aim of this study was to evaluate the effect of Tamarindus indica seed extract on the pharmacological as well as the enzymatic effects induced by V. russelli venom. Tamarind seed extract inhibited the PLA(2), protease, hyaluronidase, L-amino acid oxidase and 5'-nucleotidase enzyme activities of venom in a dose-dependent manner. These are the major hydrolytic enzymes responsible for the early effects of envenomation, such as local tissue damage, inflammation and hypotension. Furthermore, the extract neutralized the degradation of the Bp chain of human fibrinogen and indirect hemolysis caused by venom. It was also observed that the extract exerted a moderate effect on the clotting time, prolonging it only to a small extent. Edema, hemorrhage and myotoxic effects including lethality, induced by venom were neutralized significantly when different doses of the extract were preincubated with venom before the assays. On the other hand, animals that received extract 10 min after the injection of venom were protected from venom induced toxicity. Since it inhibits hydrolytic enzymes and pharmacological effects, it may be used as an alternative treatment to serum therapy and, in addition, as a rich source of potential inhibitors of PLA(2), metalloproteinases, serine proteases, hyaluronidases and 5'-nucleotidases, the enzymes involved in several physiopathological human and animal diseases. Copyright (c) 2006 John Wiley & Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: medicinal plants; Tamarind seeds; V. russelli; anti-snake venoms; natural inhibitors
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry

Agriculture Biological Sciences > Biotechnology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biotechnology
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 17 not found.
Date Deposited: 27 Apr 2013 04:55
Last Modified: 30 Nov 2015 05:28
URI: http://eprints.uni-mysore.ac.in/id/eprint/5078

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