p-halo N4-phenyl substituted thiosemicarbazones: Crystal structure, supramolecular architecture, characterization and bio-assay of their Co(III) and Ni(II) complexes

Kotian, Avinash and Karthik Kumara and Kamat, Vinayak and Naik, Krishna and Kokare, Dhoolesh G. and Anupama Nevrekar and Lokanath, N. K. and Revankar, Vidyanand K. (2018) p-halo N4-phenyl substituted thiosemicarbazones: Crystal structure, supramolecular architecture, characterization and bio-assay of their Co(III) and Ni(II) complexes. Journal of Molecular Structure, 1156. 115 - 126. ISSN 0022-2860

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Official URL: https://doi.org/10.1016/j.molstruc.2017.11.098

Abstract

In the present work, three potential metal ion chelating ligands, p-halo N4-phenyl substituted thiosemicarbazones are synthesized and characterized. The molecular structure of all (E)-4-(4-halophenyl)-1-(3-hydroxyiminobutan-2-ylidene) thiosemicarbazones (halo = F/Cl/Br) are determined by single crystal X-ray diffraction method. All the molecules have crystallized in monoclinic crystal system with P21/n space group. The ligands show CH⋯S and NH⋯S intermolecular interactions, which are responsible to form the supramolecular self-assemblies through R22(8), R22(12) and R22(14) ring motifs. Hirshfeld surface analysis is carried out to explore the intermolecular interactions. A series of Co(III) and Ni(II) mononuclear transition metal complexes derived from these ligands have been synthesized and characterized by various spectro-analytical methods. The metal to ligand stoichiometry has been found to be 1:2 in all the complexes. The synthesized compounds have been investigated for their in vitro antimicrobial potencies. The compounds are found to be more active than the standard used, in the case of E. coli and A. niger. Additionally, they are also screened for their in vitro antitubercular activity.

Item Type: Article
Uncontrolled Keywords: Thiosemicarbazones, Co(III) and Ni(II) complexes, Crystal structure, Supramolecular assembly, Hirshfeld surface analysis, Bio-assay
Subjects: D Physical Science > Physics
Divisions: Department of > Physics
Depositing User: manjula User
Date Deposited: 11 Jul 2019 06:19
Last Modified: 11 Jul 2019 06:19
URI: http://eprints.uni-mysore.ac.in/id/eprint/5077

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