Dysregulation of NRXN1 by mutant MIR8485 leads to calcium overload in pre-synapses inducing neurodegeneration in Multiple sclerosis

Yogita Kattimani and Avinash, M. V. (2018) Dysregulation of NRXN1 by mutant MIR8485 leads to calcium overload in pre-synapses inducing neurodegeneration in Multiple sclerosis. Multiple Sclerosis and Related Disorders, 22. 153 - 156. ISSN 2211-0356

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Official URL: https://doi.org/10.1016/j.msard.2018.04.005

Abstract

Objectives To identify Damaging mutations in microRNAs (miRNAs) and 3’ untranslated regions (UTRs) of target genes to establish Multiple sclerosis (MS) disease pathway. Methods Female aged 16, with Relapsing Remitting Multiple sclerosis (RRMS) was reported with initial symptoms of blurred vision, severe immobility, upper and lower limb numbness and backache. Whole Exome Sequencing (WES) and disease pathway analysis was performed to identify mutations in miRNAs and UTRs. Results We identified Deleterious/Damaging multibase mutations in MIR8485 and NRXN1. miR-8485 was found carrying frameshift homozygous deletion of bases CA, while NRXN1 was found carrying nonframeshift homozygous substitution of bases CT to TC in exon 8 replacing Serine with Leucine. Conclusions Mutations in miR-8485 and NRXN1 was found to alter calcium homeostasis and NRXN1/NLGN1 cell adhesion molecule binding affinities. The miR-8485 mutation leads to overexpression of NRXN1 altering pre-synaptic Ca2+ homeostasis, inducing neurodegeneration.

Item Type: Article
Uncontrolled Keywords: miR-8485, NRXN1, UTRs, Multiple sclerosis, Calcium homeostasis, Neurodegeneration
Subjects: B Life Science > Genetics and Genomics
Divisions: Department of > Genetics and Genomics
Depositing User: manjula User
Date Deposited: 10 Jul 2019 06:00
Last Modified: 10 Jul 2019 06:00
URI: http://eprints.uni-mysore.ac.in/id/eprint/5045

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