Simple and selective spectrophotometric assay of olanzapine in pharmaceuticals using iodate

Basavaiah, K. and Zenita Devi, O. and Tharpa, K. and Rajendraprasad, N. and Anil Kumar, U. R. and Hiriyana, S. G. and Vinay, K. B. (2008) Simple and selective spectrophotometric assay of olanzapine in pharmaceuticals using iodate. NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 31 (11-12). pp. 319-325.

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Abstract

A simple, selective and cost-effective spectrophotometric method is described for the determination of olanzapine (OLP) in pure form and in its tablet Conn. The method is based on the oxidation of OLP with iodate in H(2)SO(4) medium followed by the extraction of resulting iodine into chloroform and measurement of absorbance at 520 nm. The absorbance is found to increase linearly with concentration and the Beer's law is obeyed in the range 20-200 mu g ml(-1) with a correlation coefficient (r) of 0.999 (n=6). The apparent molar absorplivity and Sandell sensitivity values are 0.986 x 10(3) l mol(-1) cm(-1) and 0.317 mu g cm(-2) respectively. The slope and intercept of the equation of the repression line are 0.0032 and -0.0065. respectively. The limits of detection (LOD) and quantification are 1.76 and 5.34 mu g ml(-1), respectively. The method was validated for accuracy, precision, robustness and ruggedness. The proposed method was applied to the determination of OLP in tablets with satisfactory results. The accuracy and reliability of the method were further ascertained by recovery study via standard-addition method.

Item Type: Article
Uncontrolled Keywords: Olanzapine; assay; spectrophotometry; iodate; pharmaceuticals
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Users 8 not found.
Date Deposited: 20 Apr 2013 05:38
Last Modified: 23 Jul 2013 05:56
URI: http://eprints.uni-mysore.ac.in/id/eprint/4970

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