Molecular mechanism of action of butyric acid in Ehrlich ascites tumor cells

Bharathi P. Salimath, and Arshia Tabassum, and Anupama E. G., and Bindumalini, and Preeti G. B., and Salimath, P. V. (1999) Molecular mechanism of action of butyric acid in Ehrlich ascites tumor cells. NUTRITION RESEARCH, 19 (4). pp. 589-600.

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Official URL: http://dx.doi.org/10.1016/S0271-5317(99)00024-X

Abstract

We have shown that butyric acid (in vivo) decreased cell proliferation of Ehrlich Ascites Tumor (EAT) cells. This effect of butyric acid is attributed to induction of apoptosis in EAT cells, as evidenced by prevalent apoptotic morphology in EAT cells. Molecular effects of butyric acid (in vivo and in situ) included a dose dependent inhibition of generation of Reactive Oxygen Species(ROS) with IC50 value of 5 uM. Butyric acid inhibited neovascularization in the peritoneum of EAT bearing mice. The absence of permeability factor(s) in exudate of mice bearing EAT cells treated with butyric acid, can either be due to inhibition of secretion of growth factors or repression of their expression by butyric acid. Further, butyric acid not only activated a cytosolic phosphatase but also induced its expression as evidenced by immunological staining, using anti-phosphatase antibodies. (C) 1999 Elsevier Science Inc.

Item Type: Article
Uncontrolled Keywords: butyric acid; EAT cells; apoptosis; ROS generation; angiogenesis; phosphatase
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 13 not found.
Date Deposited: 19 Apr 2013 12:21
Last Modified: 07 Nov 2015 10:36
URI: http://eprints.uni-mysore.ac.in/id/eprint/4952

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