Plumbagin, a plant naphthoquinone with antitumor and radiomodifying properties

Devi, P. U. and Solomon, F. E. and Sharada, A. C. (1999) Plumbagin, a plant naphthoquinone with antitumor and radiomodifying properties. PHARMACEUTICAL BIOLOGY, 37 (3). pp. 231-236.

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The tumor inhibitory and radiomodifying effects of plumbagin (Pl), a naphthoquinone isolated from Plumbago rosea, on mouse Ehrlich ascites carcinoma was studied. Tumor response was assessed by increase in life span (% ILS) and animal survival at 120 days. The acute LD50 of plumbagin in normal mice was 9.4 mg/kg body weight. Single doses from 2 to 6 mg/kg Pl, given intraperitoneally (i.p.), produced inhibition of exponentially growing armors. However increases in dose above 3 mg/kg did not increase 120 clay survival significantly over that produced by 3 mg/kg. Multiple dose treatment, starling from 24 h after tumor cell inoculation, showed that a total dose of 9 mg/kg, administered in three fractions of 3 mg/kg once daily gave the maximum %ILS and tumor free survival. Combination of radiation (RT, 7.5 Gy to the abdomen) after the first Pl dose (1-3 mg/kg/fraction) synergistically increased mouse survival at 120 clays. The tumor inhibitory effect was less pronounced when treatment was started at more advanced tumor stages, but combination of low dose fractions (2.5 or 3 mg/kg/function) with RT enhanced the %ILS and animal survival. Higher dose fractions in combination with radiation were not tolerated by the mice. DNA appears to be the likely target of PI cytotoxicity; the mechanism of interaction of Pl + RT in enhancing tumor response is not clear.

Item Type: Article
Uncontrolled Keywords: Ehrlich ascites carcinoma; plumbagin; radiosensitization; Swiss albino mice; tumor inhibition
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 13 not found.
Date Deposited: 19 Apr 2013 09:00
Last Modified: 08 Aug 2013 05:20

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