Antioxidant properties of a novel flavonoid from leaves of Leucas aspera

Meghashri, S. and Vijay Kumar, H. and Shubha Gopal (2010) Antioxidant properties of a novel flavonoid from leaves of Leucas aspera. Food Chemistry, 122 (1). 105 - 110. ISSN 0308-8146

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The crude methanol extract of Leucas aspera leaves showed strong 1,1-diphenyl-2-picrylhydrazyl (DDPH) and superoxide radical-scavenging activities compared to other polarity-based extracted fractions. It was selected for purification of the bioactive compound. The activity-guided repeated fractionation of the methanol extract by silica gel column chromatography yielded a compound that exhibited strong antioxidant activity. Based on various physicochemical and spectroscopic analyses, e.g. UV, IR, 1H NMR, 13C NMR and mass spectroscopy, the bioactive compound isolated was elucidated as 5,7-dihydroxy-2-14-methoxy-15-propyl phenyl-4H-chromen-4-one (leucasin). Radical-scavenging potential and strong inhibition of lipid peroxidation in a liposome model were observed at a leucasin concentration of 40ppm. These results demonstrate the antioxidant potency of leucasin which could be the basis for its alleged health-promoting potential.

Item Type: Article
Uncontrolled Keywords: , Bioactive compound, Structure identification, Characterisation, Antioxidant activity
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: LA manjunath user
Date Deposited: 08 Jul 2019 11:25
Last Modified: 27 Jun 2022 07:18

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