An experimental design approach for optimization of spectrophotometric estimation of mirabegron in bulk and pharmaceutical formulations

Roopa, K. P. and Krishne Gowda, J. B. and Nagaraja, P. (2018) An experimental design approach for optimization of spectrophotometric estimation of mirabegron in bulk and pharmaceutical formulations. Journal of Analytical Chemistry, 73 (9). pp. 884-893. ISSN 1608-3199

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Abstract

Three simple, low-cost, sensitive and diversely applicable UV-Vis spectrophotometric methods have been developed for the estimation of drug Mirabegron. Method A is based on the reaction of Mirabegron with ninhydrin in the presence of sodium molybdate at pH 5.5. Method B is based on the reaction of the drug with 1,2-napthaquinone-4-sulphonate and cetyltrimethyl ammonium bromide in an alkaline medium. Method C is based on a redox reaction of the drug with Folin–Ciocalteu reagent in sodium carbonate medium. Beer’s law was obeyed in the concentration ranges of 2.5–22.5, 5–35, and 5–70 μg/mL for methods A, B, and C. The proposed methods can be applied to drug formulation and recommended for the routine analysis in quality control laboratories.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	06 Jul 2019 11:39
Last Modified:	17 Dec 2019 10:02
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4849

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