Prevalence of ctx-m-15-lactamase producing escherichia coli among extra-intestinal infections

Alhetar, Khadega Yahya and Lakshmidevi, N. (2015) Prevalence of ctx-m-15-lactamase producing escherichia coli among extra-intestinal infections. International Journal of Current Microbiology and Applied Sciences, 4 (5). pp. 243-250. ISSN 2319-7706

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Abstract

CTX-M-15 subtype of extended spectrum beta lactamase (ESBL) has increased in recent years around the world. The management of infections is complicated by the increasing prevalence and spectrum of antimicrobial resistance especially ESBL producing E. coli. This study is done to determine the prevalence of ESBL producing E. coli from different extra-intestinal infections. Hundred E. coli isolates have collected from Krishna Rajendra hospital, Mysore, India over a period of 10 months. The production of ESBLs has investigated using antibiotic disks and by Polymerase chain reaction (PCR) and sequencing to determine the CTX-M types. Out of 100 E. coli isolates; 94, 91,75, 69, 68 samples and 52 were resistant to ampicillin, amoxyclav, cefotaxime, ceftazidime, ceftroxime and cefepime respectively while 100, 97,91,90 were sensitive to levofloxacin, doxycycline, imipenime and amikacine respectively. PCR results have shown that 84 of E. coli strains were positive to CTX-M-15 while 16 of strains were non CTX-M. The prevalence of ESBL producing E. coli was found to be 75 and the CTX-M-15 was the predominant type among extra-intestinal pathogenic E. coli. This was significantly higher than the other data available in India which refer to the increased of control of dissemination of antibiotic resistance

Item Type: Article
Uncontrolled Keywords: E.Coli and CTX-M and Esbls and Expec and Antibiotic Resistance
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: Shrirekha N
Date Deposited: 05 Jul 2019 11:00
Last Modified: 05 Jul 2019 11:00
URI: http://eprints.uni-mysore.ac.in/id/eprint/4785

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