Multifaceted effects of antimetabolite and anticancer drug, 2-deoxyglucose on eukaryotic cancer models budding and fission yeast

Akshay, V. and D'Souza, Cletus J. M. (2017) Multifaceted effects of antimetabolite and anticancer drug, 2-deoxyglucose on eukaryotic cancer models budding and fission yeast. International Union of Biochemistry and Molecular Biology: Life, 69 (3). pp. 137-147.

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Official URL: https://doi.org/10.1002/iub.1599

Abstract

Abstract Glycolytic inhibitors are of interest therapeutically as they are effective against cancers that display increased glycolytic rate and mitochondrial defects. 2-Deoxyglucose (2-DG) is one such glycolytic inhibitor and was identified to be a competitive inhibitor of glucose. Studies from past few decades have shown that the mechanism of action of 2-DG is complex involving several metabolic and signaling pathways. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are two important models for studying metabolism, cell cycle and cell signaling. These two unicellular eukaryotes are Crabtree positive yeasts exhibiting a metabolism similar to that of cancer cells. Effects of 2-DG in yeast is of interest owing to these similarities and hence yeasts have emerged as ideal model organisms to study the mode of action and resistance to 2-DG. In this review, we summarize the studies on biological effect and resistance to 2-DG in budding and fission yeasts and give an insight into its possible mechanism of action as models for understanding cancer metabolism and drugs affecting cancer progression.

Item Type: Article
Uncontrolled Keywords: 2-deoxyglucose, budding yeast, fission yeast, glucose signaling and metabolism, cell wall integrity, cancer metabolism
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 05 Jul 2019 10:38
Last Modified: 09 May 2023 07:46
URI: http://eprints.uni-mysore.ac.in/id/eprint/4780

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