Oxidation of psychotropic drugs by bromamine-B in acidic buffer: A kinetic study using spectrophotometry

Ananda, S. and Ramananda, M. G. and Madegowda, N. M. (2001) Oxidation of psychotropic drugs by bromamine-B in acidic buffer: A kinetic study using spectrophotometry. SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 31 (9). pp. 1631-1645.

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Official URL: http://dx.doi.org/10.1081/SIM-100107709

Abstract

The kinetics of oxidation of chlorpromazine hydrochloride (CPH) and fluphenazine dihydrochloride (FPH) by bromamine-B (BAB) in pH 1.6 buffer solution has been studied spectrophotometrically at lambda (max) = 570 nm and 530 nm, respectively. The reaction rate shows a fractional-order dependence on BAB] and a first-order dependence on CPH or FPH]. The reaction rate also shows a fractional-order dependence on H+]. Additions of halide ions and the reduction product of BAB, benzenesulfonamide, and variation of the ionic strength and dielectric constant of the medium do not have any significant effect on the reaction rate. The reaction was studied at different temperatures and activation parameters were evaluated. The proposed general mechanism and the derived rate law are in agreement with the observed kinetics.

Item Type: Article
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Users 12 not found.
Date Deposited: 19 Apr 2013 13:45
Last Modified: 11 Sep 2013 05:06
URI: http://eprints.uni-mysore.ac.in/id/eprint/4746

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