Quantitation of pyrantel pamoate in pharmaceuticals using permanganate by visible spectrophotometry

Rajendraprasad, N. and Basavaiah, K. (2014) Quantitation of pyrantel pamoate in pharmaceuticals using permanganate by visible spectrophotometry. Journal of Applied Spectroscopy, 81 (1). pp. 127-133. ISSN 0021-9037

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Official URL: https://doi.org/10.1007/s10812-014-9897-6

Abstract

Two simple, accurate and precise spectrophotometric methods are developed and validated for the assay of pyrantel pamoate (PP) in pharmaceuticals. The methods employ the oxidative property of potassium permanganate (KMnO4) in acidic and alkaline conditions. In the first method (method A), PP is converted into its free base, pyrantel (PR), and treated with known excess of KMnO4 in acidic condition followed by the measurement of unreacted KMnO4 at 550 nm. Method B is based on the registration of absorbance of green colored chromogen formed due to the reduction of KMnO4 by PP in alkaline condition. The methods obeyed Beer's law over a range of 1-20 μg/ml in inverse manner, and 0.75-15 μg/ml for method A and method B, respectively, with apparent molar absorptivity values of 1.05dot operator104 and 2.85dot operator104 ldot operatormol-1dot operatorcm-1. The optical parameters such as limits of detection (LOD), quantification (LOQ), and the Sandell sensitivity values are also reported. The accuracy and precision of the methods are assessed on intra- and inter-day basis. A recovery study by standard addition procedure is also carried out for further assurance of accuracy. The developed methods are successfully applied to determine PP in tablets. The results are more satisfactory as per current ICH guidelines.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 10 Jul 2019 06:31
Last Modified: 10 Jul 2019 06:31
URI: http://eprints.uni-mysore.ac.in/id/eprint/4470

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