Implications of phytochemicals in snakebite management: Present status and future prospective

Urs, N. A. N. and Yariswamy, M. and Joshi, V. and Nataraju, A. and Veerabasappa Gowda, T. and Vishwanath, B. S. (2014) Implications of phytochemicals in snakebite management: Present status and future prospective. Toxin Reviews, 33 (3). pp. 60-83.

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In spite of vast advances in healthcare services, treatment of snakebite still remains a challenge to medical fraternity, because of unresolved complications of severe local tissue damage and consequential physical disabilities. Though anti-venom therapy reduces mortality, is ineffective against local tissue damage. In vitro and in vivo studies demonstrated that several alkaloids, flavonoids, polyphenols, terpenoids, saponins, sterols, glycosides, etc., from herbal medicines effectively neutralized local tissue damage induced by venom toxins/enzymes. This review emphasizes the interplay of venom toxins/enzymes in local toxicity and their neutralization using phytochemicals. Further, approaches using phytochemicals and anti-venoms are reviewed for better management of snakebite.

Item Type: Article
Uncontrolled Keywords: human, nonhuman, toxicity, snake venom, morbidity, phospholipase A2, medicinal plant, herbal medicine, tissue injury, pathophysiology, hyaluronidase, snakebite, metalloproteinase, neurotoxicity, review, plant medicinal product, chemical modification, proteinase, envenomation, snake venom antiserum, muscle disease, myotoxicity, blood clotting disorder, hospital management, serine proteinase, traditional healer
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 19 Aug 2019 11:06
Last Modified: 12 Jul 2022 07:02

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