Synthesis and characterization of novel benzod1,3dioxole gathered pyrazole derivatives and their antimicrobial evaluation

Umesha, B. and Basavaraju, Y. B. (2014) Synthesis and characterization of novel benzod1,3dioxole gathered pyrazole derivatives and their antimicrobial evaluation. Medicinal Chemistry Research, 23 (8). pp. 3744-3751. ISSN 1554-8120

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Abstract

Benzod1,3dioxole gathered pyrazole derivatives (4a-i) were synthesized by the reaction of chalcones with phenyl hydrazine in presence of absolute alcohol as a solvent. Chalcones were prepared by the Claisen-Schmidt reaction between 1-(benzod1,3dioxol-5-yl)ethanone (2) and substituted aromatic aldehydes. The synthesized compounds were characterized by spectral and elemental analysis data. Furthermore, Benzo d1,3dioxole gathered pyrazole derivatives (4a-i) were evaluated for their in vitro antimicrobial activity. Among the newly synthesized compounds 4a, 4c, 4 g and 4 h showed the excellent antifungal activity and as well as 4a and 4d showed the excellent antibacterial activity when compared to other compounds.

Item Type:	Article
Uncontrolled Keywords:	4, carbon nuclear magnetic resonance, controlled study, drug potency, drug synthesis, in vitro study, infrared spectroscopy, nonhuman, proton nuclear magnetic resonance, structure activity relation, unclassified drug, drug screening, pyrazole derivative, antibacterial activity, antifungal activity, antiinfective agent, gentamicin, article, minimum inhibitory concentration, 3 (benzod1, chalcone derivative, electrospray mass spectrometry, antimicrobial activity, fluconazole, chemical reaction, alcohol, aldehyde, conformational transition, 1 (benzod]1, 3dioxol 5 yl) 1, 3dioxol 5 yl) 1 phenyl 5, 3dioxol 5 yl) 1 phenyl 5 (3, 3dioxol 5 yl) 5 (2 isopropylphenyl) 1h pyrazole, 3dioxol 5 yl) 5 (2 nitrophenyl) 1 phenyl 1h pyrazole, 3dioxol 5 yl) 5 (3, 3dioxol 5 yl) 5 (4 nitrophenyl) 1 phenyl 1h pyrazole, 3dioxol 5 yl) 5 4 (methylthio)phenyl 1 phenyl 1h pyrazole, 3dioxol 5 yl)ethanone, 3dioxole derivative, 4 dimethoxyphenyl) 1 phenyl 1h pyrazole, 4 dimethylphenyl) 1h pyrazole, 4 tolyl 1h pyrazole, 5 diphenyl 1h pyrazole, 5 trimethoxyphenyl) 1h pyrazole, benzene derivative, benzod1, Claisen Schmidt reaction, phenylhydrazine
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	20 Aug 2019 07:42
Last Modified:	20 Aug 2019 07:42
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4399

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