Simple and rapid spectrophotometric assay of albendazole in pharmaceuticals using iodine and picric acid as CT complexing agents

Swamy, N. and Basavaiah, K. (2014) Simple and rapid spectrophotometric assay of albendazole in pharmaceuticals using iodine and picric acid as CT complexing agents. Brazilian Journal of Pharmaceutical Sciences, 50 (4). pp. 839-850. ISSN 2175-9790 (In Press)

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Abstract

Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in tablets. The methods are based on charge-transfer (CT) complexation reaction involving ALB as n-donor and iodine as �-acceptor (method A) in dichloromethane or picric acid (PA) as �-acceptor (method B) in chloroform. The absorbance of CT complexes was measured at 380 nm for method A, and 415 nm for method B. The optimization of the experimental conditions is described. Under optimum conditions, Beer�s law obeyed over the concentration ranges 8.0-240 and 2.4-42 mg mL -1 for method A and method B, respectively. The apparent molar absorptivity of CT complexes at the respective λ max are calculated to be 1.17�10 3 and 5.22�10 3 L mol -1 cm -1 respectively, and the corresponding Sandell sensitivity values are 0.2273 and 0.0509 ng cm-2. The limits of detection (LOD) and quantification (LOQ) are calculated to be (0.69 and 2.08), and (0.10 and 0.30) mg mL -1 with method A, and method B, respectively. The intra-day and inter-day accuracy expressed as % RE and precision expressed as % RSD were less than 3%. The methods were applied to the determination of ALB in tablets.

Item Type:	Article
Uncontrolled Keywords:	Article, controlled study, drug structure, concentration (parameters), validation study, limit of quantitation, drug determination, limit of detection, process optimization, reaction time, picric acid, spectrophotometry, accuracy, intermethod comparison, iodine, solvent effect, complex formation, reaction analysis, surface charge, albendazole
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	23 Aug 2019 06:56
Last Modified:	23 Aug 2019 06:56
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4368

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