LmTDRM database: a comprehensive database on thiol metabolic gene/gene products in Listeria monocytogenes EGDe

Srinivas, V. and Shubha Gopal (2014) LmTDRM database: a comprehensive database on thiol metabolic gene/gene products in Listeria monocytogenes EGDe. Journal of integrative bioinformatics, 11 (1). p. 245. ISSN 1613-4516

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Abstract

There are a number of databases on the Listeria species and about their genome. However, these databases do not specifically address a set of network that is important in defence mechanism of the bacteria. Listeria monocytogenes EGDe is a well-established intracellular model organism to study host pathogenicity because of its versatility in the host environment. Here, we have focused on thiol disulphide redox metabolic network proteins, specifically in L. monocytogenes EGDe. The thiol redox metabolism is involved in oxidative stress mechanism and is found in all living cells. It functions to maintain the thiol disulphide balance required for protein folding by providing reducing power. Nevertheless, they are involved in the reversible oxidation of thiol groups in biomolecules by creating disulphide bonds; therefore, the term thiol disulphide redox metabolism (TDRM). TDRM network genes play an important role in oxidative stress mechanism and during host–pathogen interaction. Therefore, it is essential to have detailed information on these proteins with regard to other bacteria and its genome analysis to understand the presence of tRNA, transposons, and insertion elements for horizontal gene transfer. LmTDRM database is a new comprehensive web-based database on thiol proteins and their functions. It includes: Description, Search, TDRM analysis, and genome viewer. The quality of these data has been evaluated before they were aggregated to produce a final representation. The web interface allows for various queries to understand the protein function and their annotation with respect to their relationship with other bacteria. LmTDRM is a major step towards the development of databases on thiol disulphide redox proteins; it would definitely help researchers to understand the mechanism of these proteins and their interaction. Database URL: www.lmtdrm.com.

Item Type:	Article
Uncontrolled Keywords:	human, animal, Animals, Humans, metabolism, genetics, physiology, Databases, thiol derivative, Genetic, Bacterial, Genes, bacterial protein, Bacterial Proteins, Listeria monocytogenes, gene regulatory network, genetic database, bacterial gene, Gene Regulatory Networks, Gene Transfer, Horizontal, horizontal gene transfer, listeriosis, Listeriosis, protein folding, Protein Folding, Sulfhydryl Compounds
Subjects:	B Life Science > Microbiology
Divisions:	Department of > Microbiology
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	23 Aug 2019 06:08
Last Modified:	23 Aug 2019 06:08
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4363

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