Synthesis of novel 1, 4-benzothiazepines and in vitro screening of their antimicrobial activity

Raghavendra, K. R. and Ajay Kumar, K. and Shashikanth, S. (2014) Synthesis of novel 1, 4-benzothiazepines and in vitro screening of their antimicrobial activity. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (5). pp. 90-93. ISSN 0975-1491

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Abstract

Objective: In search of new potential antimicrobial agents, the aim of the present study was synthesize the series of 1, 4-Benzothiazepine analogs by a simple and accessible approach and evaluate for their antimicrobial activity. Methods: Synthetic methodology involves the reaction of an α, β-unsaturated ketones (3 and 6) with 2-aminothiophenol and 3-4 drops of conc. HCl in methanol at 160°C, which afforded a series of novel 1,4-thiazepine derivatives (4a-f and 7a-c) in good yields. Results: The structures of the synthesized compounds were provided by spectral and elemental analysis, and by single crystal X-ray diffraction studies. The synthesised compounds were tested for their antimicrobial activity against different fungi and bacteria species in vitro. Conclusion: The results of the study reveal that the new compounds possess promising antimicrobial activities.

Item Type: Article
Uncontrolled Keywords: 4, carbon nuclear magnetic resonance, drug synthesis, in vitro study, nonhuman, proton nuclear magnetic resonance, unclassified drug, X ray diffraction, drug screening, polymerization, Aspergillus niger, Bacillus subtilis, Escherichia coli, Fusarium oxysporum, article, minimum inhibitory concentration, antimicrobial activity, nystatin, ciprofloxacin, disk diffusion, hydrochloric acid, ketone, 2 (3, 2 (4 (thiophen 2 yl) 2, 2 (4 ethylphenyl) 4 (thiophen 2 yl) 2, 2 (benzod1, 2 aminothiophenol, 2 methoxy 4 (4 (thiophen 2 yl) 2, 2 methyl 4 phenyl 2, 3 dihydrobenzob]1, 3dioxol 4 yl) 4 (thiophen 2 yl) 2, 4 (2 (2, 4 (4 chlorophenyl) 2 (3, 4 (thiophen 2 yl) 2 (3, 4 dichlorophenyl) 2, 4 dimethoxyphenyl) 2, 4 dimethoxyphenyl) 4 (thiophen 2 yl) 2, 4thiazepin 2 yl)phenol, 4thiazepin 4 yl)aniline, 4thiazepine, 5 trimethoxyphenyl) 2, benzothiazepine derivative, Staphylococus aureus
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 28 Aug 2019 06:11
Last Modified: 28 Aug 2019 06:11
URI: http://eprints.uni-mysore.ac.in/id/eprint/4357

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