Copy number variations burden on mirna genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression

Veerappa, A. M. and Murthy, M. and Vishweswaraiah, S. and Lingaiah, K. and Suresh, R. V. and Nachappa, S. A. and Prashali, N. and Yadav, S. N. and Srikanta, M. A. and Manjegowda, D. S. and Seshachalam, K. B. and Ramachandra, N. B. (2014) Copy number variations burden on mirna genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression. PLoS ONE, 9 (2). ISSN 1932-6203

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Official URL: https://doi.org/10.1371/journal.pone.0090391

Abstract

MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known. From a total of 44109 CNVs investigated from 1715 individuals across 12 populations using high-throughput arrays, 4007 miRNA-CNVs (,9%) consisting 6542 (,5%) miRNA genes with a total of 333 (,5%) singleton miRNA genes were identified. We found miRNA-CNVs across the genomes of individuals showing multiple hits in many targets, co-regulated under the same pathway. This study proposes four mechanisms unraveling the many complexities in miRNA genes, targets and co-regulated miRNA genes towards establishment of phenotypic diversity.

Item Type: Article
Uncontrolled Keywords: controlled study, human, Humans, adult, male, female, Gene Expression Regulation, Chromosome Mapping, Chromosomes, aged, major clinical study, adolescent, sex difference, gene expression, article, gene frequency, genetic association, genetic variability, Genetics, Genome, Population, Computational Biology, signal transduction, gene identification, microRNA, Genotype, phenotype, Phenotype, Human, copy number variation, DNA Copy Number Variations, Genetic Predisposition to Disease, Metabolic Networks and Pathways, MicroRNAs, chromosome analysis, gene mapping, inheritance, microRNA gene, mutation rate
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: Arshiya Kousar
Date Deposited: 30 Aug 2019 05:31
Last Modified: 30 Aug 2019 05:31
URI: http://eprints.uni-mysore.ac.in/id/eprint/4335

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