Prashanth, P. A. and Kempe Gowda, B. K. and Ananda, S. and Rangappa, K. S. and Kumara, M. N. (2014) Ru(III) chloride-catalysed oxidation of some α-amino acids by sodium-N-chloro-p-toluenesulfonamide(CAT) in hydrochloric acid medium: Mechanistic investigation and kinetic modeling. Journal of Molecular Catalysis A: Chemical, 383-38. pp. 203-208.
Full text not available from this repository. (Request a copy)Abstract
The kinetics of the ruthenium(III) chloride Ru(III)-catalysed oxidation of four α-amino acids (AA) viz. glycine (Gly), valine (Val), alanine (Ala) and leucine (Leu) by sodium N-chloro-p-toluenesulfonamide (CAT: Chloramine-T) in the presence of hydrochloric acid medium has been studied at 308 K. The oxidation reaction follows the identical kinetics for all the four amino acids and obeys the rate law, rate= k� CATo Sox H + y Ru(III), where x and y are fractions. Variation of ionic strength of the medium, addition of the halide ions and the reaction product (PTS: p-toluenesulfonamide) show negligible effect on rate of the reaction. Solvent composition shows positive effect indicating that positive ion-dipolar molecule involved in the rate determining step. The oxidation products were identified. The activation parameters have been evaluated from the Arrhenius plots. The activation energy values are least for the fastest reactions and vice versa. The large negative value of �S � and the high value of �G � support the proposed mechanism. Under comparable experimental conditions, the rate of oxidation of amino acids increases in the order: Leu \> Ala \> Val \> Gly. This trend may be attributed to hydrophobicity, nucleophilicity and inductive effect of amino acids. The reaction mechanism and the derived rate law are consistent with the observed experimental results.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Chlorine compounds, Catalysis, Amino acids, Activation energy, Reaction mechanism, Ionic strength, Kinetics, Oxidation, Hydrochloric acid, Activation parameter, Arrhenius plots, Chloramine-T, Experimental conditions, Hydrochloric acid medium, Oxidation reactions, p-Toluenesulfonamide, Rate determining step |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry Yuvaraj college > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 29 Aug 2019 09:54 |
| Last Modified: | 29 Aug 2019 09:54 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4328 |
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