Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis

Vijay Avin, B. R. and Thirusangu, P. and Lakshmi Ranganatha, V. and Firdouse, A. and Prabhakar, B. T. and Khanum, S. A. (2014) Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis. European Journal of Medicinal Chemistry, 75. pp. 211-221. ISSN 0223-5234

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Official URL: https://doi.org/10.1016/j.ejmech.2014.01.050

Abstract

A sequence of coumarin analogs 5a-j was obtained by multi step synthesis from hydroxy benzophenones (1a-j). The in vitro antiproliferative effect of the title compounds was tested against Ehrlich ascites carcinoma (EAC) and Daltons lymphoma ascites (DLA) cell lines. Among the series, compound 5c with bromo group in the benzophenone moiety was endowed with excellent antiproliferative potency with significant IC50 value. Further, in vivo antitumor effect of compound 5c against murine EAC and solid DL tumor model system was evident by the extended survivality. The tumor inhibitory mechanism of compound 5c was due to the antiangiogenesis and promotion of apoptosis. These results suggest possible applications of compound 5c which could be developed as a potent anticancer drug in the near future.

Item Type: Article
Uncontrolled Keywords: Animals, Antineoplastic Agents, Antitumor, Cell Line, Humans, Tumor, Female, Apoptosis, Antiangiogenic, Benzophenones, Neovascularization, Mice, Carcinoma, Coumarins, Pathologic, Angiogenesis Inhibitors, Ehrlich Tumor, Lymphoma, Coumarin analogs, Proapoptotic
Subjects: C Chemical Science > Biochemistry
C Chemical Science > Chemistry
Divisions: Yuvaraj college > Bio-Chemistry
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 30 Aug 2019 10:06
Last Modified: 30 Aug 2019 10:06
URI: http://eprints.uni-mysore.ac.in/id/eprint/4319

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