Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

Sharath Kumar, K. S. and Hanumappa, A. and Hegde, Mahesh and Narasimhamurthy, K. H. and Raghavan, S. C. and Rangappa, K. S. (2014) Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells. European Journal of Medicinal Chemistry, 81. pp. 341-349. ISSN 0223-5234

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Abstract

The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl) benzoate (5) displayed potent activity (IC509.71, 15.24 and 19.29 μM) against Nalm6, K562, Jurkat cells. Cell cycle analysis and mitochondrial membrane potential further confirmed that compound 5 is cytotoxic and able to induce cell death.

Item Type:	Article
Uncontrolled Keywords:	Thiazolidinones, Propylphosphonic anhydride (T3P®) Leukemia, Cytotoxicity, Chemotherapeutics, Apoptosis
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	31 Aug 2019 09:44
Last Modified:	24 Mar 2025 05:16
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4307

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