Tabassum, S. and Suresha Kumara, T. H. and Jasinski, J. P. and Millikan, S. P. and Yathirajan, H. S. and Sujan Ganapathy, P. S. and Sowmya, H. B. V. and More, S. S. and Nagendrappa, G. and Kaur, M. and Jose, G. (2014) Synthesis, crystal structure, ABTS radical-scavenging activity, antimicrobial and docking studies of some novel quinoline derivatives. Journal of Molecular Structure, 1070 (1). pp. 10-20. ISSN 0022-2860
Full text not available from this repository. (Request a copy)Abstract
In this study, a series of nine novel 2-chloroquinolin-3-yl ester derivatives have been synthesized via a two-step protocol from 2-chloroquinoline-3-carbaldehyde. The structures of all these compounds were confirmed by spectral data. The single crystal X-ray structure of two derivatives, (2-chloroquinolin-3-yl)methyl acetate 6a and (2-chloro-6- methylquinolin-3-yl)methyl acetate 6e have also been determined. The synthesized compounds were further evaluated for their ABTS radical-scavenging activity and antimicrobial activities. Amongst all the tested compounds, 6a exhibited maximum scavenging activity with ABTS. Concerning antibacterial and antifungal activities, compound (2-chloro-6-methoxyquinolin-3-yl)methyl 2,4-dichlorobenzoate 6i was found to be the most active in the series against B. subtilis, S. aureus, E. coli, K. pneumonia, C. albicans and A. niger species. The structure-antimicrobial activity relationship of these derivatives were studied using Autodock.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Synthesis (chemical), Bacillus subtilis, Candida albicans, Escherichia coli, Staphylococcus aureus, Microorganisms, Antimicrobial study, Docking studies, Quinoline, Radical-scavenging activities, Single crystal x-ray structures, Vilsmeier-Haack reaction, Volatile fatty acids |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 31 Aug 2019 08:01 |
| Last Modified: | 31 Aug 2019 08:01 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4302 |
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