Extraction-free spectrophotometric determination of pyrantel pamoate in pharmaceuticals

Swamy, N. and Basavaiah, K. and Vinay, K. B. (2014) Extraction-free spectrophotometric determination of pyrantel pamoate in pharmaceuticals. Proceedings of the Indian National Science Academy, 80 (3). pp. 597-608. ISSN 0370-0046

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The objective of this work was to develop and validate two direct, simple, highly sensitive, rapid and extraction-free spectrophotometric methods for the determination of Pyrantel pamoate (PYP) in commercial dosage forms. The methods are based on the formation of ion-pair complex between the base form of Pyrantel pamoate (PYL) and two sulphonthalein dyes, namely, phenol red (method A) and thymol blue (method B), followed by the measurement of absorbance at 430 nm and 420 nm respectively. Conformity to Beer's law enabled the assay of drug in the range 0.02-0.5 and 0.05-0.8 μg ml 1 with apparent molar absorptivitics of 5.11 � 105 and 2.55 � 10s 1 mol-1 cnr-1 for method A and method B, respectively. The Sandell sensitivity values, limits of detection (LOD) and quantification (LOQ) values have also been reported for both the methods. The stoichiometry of the ion-pair complexes as evaluated by Job's continuous variations method was 1:2 and the conditional stability constants (log Kf) were calculated to be 6.92 and 8.19 for method A and method B, respectively. The accuracy and precision of the methods were evaluated on intra-day and inter-day basis; the relative error (%RE) was < 2.17% and the relative standard deviation (RSD) was < 1.77%. The methods were successfully applied to the determination of drug in tablets without interference by the common co-formulated substances. Statistical comparison of the results with the reference method showed good agreement and indicated that no significant difference in accuracy and precision.

Item Type: Article
Uncontrolled Keywords: Phenols, Extraction, Ions, Spectrophotometry, Spectrophotometers, Dosage forms, Phenol red, Ion pairs, Pyrantel pamoate, Thymol blues
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 31 Aug 2019 06:12
Last Modified: 31 Aug 2019 06:12
URI: http://eprints.uni-mysore.ac.in/id/eprint/4299

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