Molecular interaction network and pathway studies of ADAM33 potentially relevant to asthma

Vishweswaraiah, S. and Veerappa, A. M. and Mahesh, P. A. and Jayaraj, B. S. and Krishnarao, C. S. and Ramachandra, N. B. (2014) Molecular interaction network and pathway studies of ADAM33 potentially relevant to asthma. Annals of Allergy, Asthma and Immunology, 113 (4). 418-424.e1. ISSN 1081-1206

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Background: Asthma is a complex disease caused by geneegene, geneeprotein, and proteineprotein interactionsand the influence of environment, which plays a significant role in causing asthma pathogenesis.ADAM33 is known to be an important gene involved in asthma pathogenesis. No one single gene is a causalfactor of asthma; rather, asthma is caused by a complex interaction of multiple genes having pathogeneticand protective effects. Objective: To identify and understand the interacting genes and proteins of ADAM33. Methods: The Ingenuity Pathway Analysis and GeneMANIA tools and a literature survey were used toidentify the interacting candidates of ADAM33 and the WEB-based GEne SeT AnaLysis Toolkit was used toperform enrichment analysis of the proteins identified. Results: Keeping ADAM33 as a major hub, the authors identified some proteins whose interaction withADAM33 had been associated with asthma and they recognized some proteins, such as amyloid b (A4)precursor protein, ataxin-7, a4-integrin, a5-integrin, a9-integrin, tissue inhibitor of metalloproteinase-4, andubiquilin-4, that had not been previously associated with asthma. Conclusion: The proteins identified in this study were enriched for various mechanisms that are involved inairway hyperresponsiveness, and through the interaction with ADAM33, they may have potential relevancein asthma.

Item Type: Article
Uncontrolled Keywords: Article, controlled study, human, unclassified drug, fibroblast, Fibroblasts, Humans, metabolism, pathology, protein expression, genetics, gene expression, bioinformatics, protein function, gene, gene function, pathogenesis, protein protein interaction, disease association, gene identification, microRNA, Internet, Epithelial Cells, epithelium cell, extracellular matrix, Extracellular Matrix, asthma, Asthma, interleukin 13, interleukin 4, Interleukin-13, protein determination, complex formation, data analysis software, ADAM protein, ADAM Proteins, ADAM33 gene, ADAM33 protein, alpha integrin, alpha4 integrin, alpha5 integrin, alpha9 integrin, amyloid beta protein, amyloid precursor protein, ataxin 7, Bronchial Hyperreactivity, bronchus hyperreactivity, causal attribution, gene interaction, gene regulatory network, genetic correlation, genetic database, IL4 protein, Interleukin-4, Metabolic Networks and Pathways, MicroRNAs, Myocytes, Protein Structure, protein tertiary structure, respiratory tract allergy, Smooth Muscle, smooth muscle fiber, Tertiary, tissue inhibitor of metalloproteinase, tissue inhibitor of metalloproteinase 4, Tissue Inhibitor of Metalloproteinases, ubiquilin 4, ubiquitinated protein
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 03 Sep 2019 09:44
Last Modified: 11 Dec 2019 06:16

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