Ningegowda, R. and Grover, A. and Basappa, S. and Rangappa, K. S. (2010) synthesis, characterization and in vitro anti-tumor activities of novel 9-ethyl-9H-purine derivatives. Investigational New Drugs, 28 (6). pp. 754-765. ISSN 0167-6997
Full text not available from this repository. (Request a copy)Abstract
Newer series of 9-ethyl-9H-purine derivatives (EPD) were synthesized and screened for their efficacy in inhibiting the proliferation of various tumor cells in vitro. We evaluated the effects of EPD against HeLa, SiHa, CaSki (human cervical cancer cells), LM8, LM8G7 (murine osteosarcoma cells), OVSAHO and SKOV-3 (human ovarian cancer cells). The chemical structures of the EPD were confirmed by (1)H NMR and LCMS analyses. The inhibitory effects of EPD were studied by using trypan blue exclusion, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and TetraColor One reagents. Furthermore, SAR studies revealed that the presence of trifluoromethoxy and trifluromethyl group in 4b and 4g, respectively are responsible for the significant activity of the EPD against cervical cancer cells and the presence of isopropoxy group in 4f has influence in inhibiting the proliferation of osteosarcoma and ovarian cancer cell types.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | LA manjunath user |
| Date Deposited: | 29 Jun 2019 11:02 |
| Last Modified: | 28 Dec 2020 06:08 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4160 |
Actions (login required)
 |
View Item |
