Use of Pavo cristatus feather extract for the better management of snakebites: Neutralization of inflammatory reactions

Murari, S. K. and Frey, F. J. and Frey, B. M. and Gowda, T. Veerabasappa and Vishwanath, B. S. (2005) Use of Pavo cristatus feather extract for the better management of snakebites: Neutralization of inflammatory reactions. JOURNAL OF ETHNOPHARMACOLOGY, 99 (2). pp. 229-237.

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Official URL: http://dx.doi.org/10.1016/j.jep.2005.02.027

Abstract

In Indian traditional medicine, peacock feather in the form of ash (Bhasma) or water extract are used against snakebite and to treat various problems associated with lungs. This study was aimed to evaluate the water extract of peacock feather (PCF) against the local tissue damage caused due to snakebite. PCF water extract showed inhibition towards phospholipase A, enzyme activity from snake venom (Naja naja and Vipera russelii), inflammatory fluids (synovial, pleural, ascites) and normal serum in a dose-dependent manner. Hyaluronidase and proteases are other major enzymes in snake venoms responsible for local tissue damage. PCF water extract inhibited hyaluronidase and proteolytic enzyme activities from Vipera russelii, Naja naja and Trimeresurus malabaricus venom. The active principle is a hydrophilic molecule easily extractable in water or polar solvents. PCF water extract gave positive results for the presence of protein and secondary metabolites like carotenoids and steroids. Analysis of metal ions revealed that iron is the major ion (> 20-fold). Other metal ions detected in smaller amount are copper, chromium, zinc and nickel. The least amount of ion detected is gold. Co-injection of PCF water extract with snake venom and inflammatory PLA(2) enzymes neutralize the edema inducing activity of all the PLA(2) enzymes studied. Since it inhibits hyaluronidase and proteases enzyme activity from snake venom PCF water extract is a powerful neutralizing agent, which has therapeutic application against venom toxicity. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Pavo cristatus; phospholipase A(2); hyaluronidases; proteases anti-inflammatory activity; synovial fluid; metal ions; snake venom
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 9 not found.
Date Deposited: 12 Apr 2013 05:15
Last Modified: 11 Sep 2013 06:07
URI: http://eprints.uni-mysore.ac.in/id/eprint/4079

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