Local tissue destruction and procoagulation properties of Echis carinatus venom: Inhibition by Vitis vinifera seed methanol extract

Mahadeswaraswamy, Y. H. and Nagaraju, S. and Girish, K. S. and Kemparaju, K. (2008) Local tissue destruction and procoagulation properties of Echis carinatus venom: Inhibition by Vitis vinifera seed methanol extract. PHYTOTHERAPY RESEARCH, 22 (7). pp. 963-969.

Full text not available from this repository. (Request a copy)
Official URL: http://dx.doi.org/10.1002/ptr.2462

Abstract

Plant extracts are extensively used against snakebites in Indian folk medicine. In this study, one such traditionally used plant, Vitis vinifera L. (Vitaceae) seed methanol extract has been studied for its ability to neutralize Indian Echis carinatus (saw-scaled viper) venom. The extract effectively inhibited toxic effects, such as oedema, haemorrhage, myonecrosis and coagulation of citrated human plasma. Further, the extract inhibited the caseinolytic, hyaluronolytic and fibrinogenolytic activities of the venom. The extract caused dose dependent inhibition of the toxic activities studied, suggesting venom inhibition. Thus, the anti-snake venom property of the extract appears to be highly promising for further investigation in order to achieve better neutralization of Indian E. carinatus venom poisoning. Copyright (c) 2008 John Wiley & Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: Echis carinatus venom; grape seeds; haemorrhage; methanol extract; venom inhibition
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 8 not found.
Date Deposited: 10 Apr 2013 05:56
Last Modified: 02 May 2013 08:55
URI: http://eprints.uni-mysore.ac.in/id/eprint/4062

Actions (login required)

View Item View Item