Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity

Mallikarjunaswamy, C. and Bhadregowda, D. G. and Mallesha, L. (2016) Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity. Journal of Saudi Chemical Society, 20. S606 - S614. ISSN 1319-6103)

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Abstract

A series of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi.

Item Type:	Article
Uncontrolled Keywords:	Pyrimidines, Schiff bases, Antimicrobial activity, Antifungal activity
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	28 Jun 2019 05:40
Last Modified:	28 Jun 2019 05:40
URI:	http://eprints.uni-mysore.ac.in/id/eprint/4037

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