Genes controlling 2-deoxyglucose induced Lysis and formation of reactive oxygen species in Schizosaccharomyces pombe

Akshay, V. and D’Souza, C. J. M. and Schweingruber, Martin E. (2017) Genes controlling 2-deoxyglucose induced Lysis and formation of reactive oxygen species in Schizosaccharomyces pombe. Polish Journal of Microbiology, 66 (3). pp. 393-396. ISSN 2544-4646

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Abstract

Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpressing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). Here we report that these genes control 2-DG induced lysis and are, with the exception of odr1, also involved in control of formation of reactive oxygen species (ROS) upon exposure of cells to H2O2. Lysis of deletion strains, but not of strain overexpressing odr1, is dependent on glucose concentration of the medium whereas ROS formation is glucose independent.

Item Type:	Article
Uncontrolled Keywords:	2-deoxyglucose, fission yeast, glucose signaling, lysis, ROS formation
Subjects:	C Chemical Science > Biochemistry
Divisions:	Department of > Biochemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	26 Jun 2019 09:36
Last Modified:	09 May 2023 07:45
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3884

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