Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities

Renuka Nagamallu and Bharath, S. and Mylarappa, N. B. and Ajay Kumar, K. (2016) Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities. Bioorganic & Medicinal Chemistry Letters, 26 (2). 690 - 694.

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Official URL: https://doi.org/10.1016/j.bmcl.2015.11.038

Abstract

A series of novel coumarin pyrazole hybrids of biological interest were synthesized from the hydrazones, carbazones and thiocarbazones via Vilsmeier Haack formylation reaction. These intermediates and formyl pyrazoles were evaluated for antimicrobial and antioxidant activities. Among the series, compounds 6g and 6h showed excellent antimicrobial activity against different bacterial and fungal strains and compounds 7g, 7h were found to be potent antioxidant agents in both DPPH and hydroxyl radical scavenging assays. Further, detailed quantitative structure–activity relationship (QSAR) analysis indicated the molecular parameters that contribute to increased potency of inhibition. The above findings would further encourage our understanding in employing coumarin pyrazole hybrids as potential antibiotic agents for treating infections caused by pathogenic microbes and fungi. Further, it also paves the way for exploration of these compounds as potential therapeutic agents to treat conditions arising because of excessive oxidative damage.

Item Type: Article
Uncontrolled Keywords: Antioxidant, Antimicrobial, Coumarin, DPPH, Hydroxyl radical, MIC, Pyrazole
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: manjula User
Date Deposited: 25 Jun 2019 06:33
Last Modified: 25 Jun 2019 06:33
URI: http://eprints.uni-mysore.ac.in/id/eprint/3807

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