Differential action of medically important Indian BIG FOUR snake venoms on rodent blood coagulation

Hiremath, Vilas and Nanjaraj Urs, A. N. and Joshi, Vikram and Suvilesh, K. N. and Savitha, M. N. and Amog, Prathap Urs and Rudresha, G. V. and Yariswamy, M. and Vishwanath, B. S. (2016) Differential action of medically important Indian BIG FOUR snake venoms on rodent blood coagulation. Toxicon, 110. 19 - 26.

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Official URL: https://doi.org/10.1016/j.toxicon.2015.11.014

Abstract

Snakebite is a global health problem affecting millions of people. According to WHO, India has the highest mortality and/or morbidity due to snakebite. In spite of commendable research on Indian BIG FOUR venomous species; Naja naja and Bungarus caeruleus (elapid); Daboia russelii and Echis carinatus (viperid), no significant progress has been achieved in terms of diagnosis and management of biting species with appropriate anti-snake venom. Major hurdle is identification of offending species. Present study aims at differentiation of Indian BIG FOUR snake venoms based on their distinguish action on rodent blood coagulation. Assessment of coagulation alterations by elapid venoms showed negligible effect on re-calcification time, prothrombin time, activated partial thromboplastin time and factors assay (I, II, V, VIII and X) both in vitro and in vivo. However, viperid venoms demonstrated significant anticoagulant status due to their remarkable fibrinogen degradation potentials as supported by fibrinogenolytic activity, fibrinogen zymography and rotational thromboelastometry. Though results provide hint on probable alterations of Indian BIG FOUR snake venoms on blood coagulation, the study however needs validation from human victim's samples to ascertain its reliability for identification of biting snake species.

Item Type: Article
Uncontrolled Keywords: BIG FOUR, Blood coagulation, Elapid and viperid venoms, Fibrinogen, Rotational thromboelastometry
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: manjula User
Date Deposited: 25 Jun 2019 06:02
Last Modified: 30 Jul 2019 06:08
URI: http://eprints.uni-mysore.ac.in/id/eprint/3800

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